North American Neuromodulation Society
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NANS Neuromodulation Journal Club



Presented Article: Learning to Control the Brain through Adaptive Closed-Loop Patterned Stimulation
Date: Tuesday, February 9, 2021
Time: 3 pm CST / 4 pm EST

Tafazoli S, MacDowell CJ, Che Z, Letai KC, Steinhardt C, Buschman TJ. Learning to Control the Brain through Adaptive Closed-Loop Patterned Stimulation. bioRxiv. 2020 Jan 1. 

Stimulation of neural activity is an important scientific and clinical tool, causally testing hypotheses and treating neurodegenerative and neuropsychiatric diseases. However, current stimulation approaches cannot flexibly control the pattern of activity in populations of neurons. To address this, we developed an adaptive, closed-loop stimulation (ACLS) system that uses patterned, multi-site electrical stimulation to control the pattern of activity in a population of neurons. Importantly, ACLS is a learning system; it monitors the response to stimulation and iteratively updates the stimulation pattern to produce a specific neural response. In silico and in vivo experiments showed ACLS quickly learns to produce specific patterns of neural activity (~15 minutes) and was robust to noise and drift in neural responses. In visual cortex of awake mice, ACLS learned electrical stimulation patterns that produced responses similar to the natural response evoked by visual stimuli. Similar to how repetition of a visual stimulus causes an adaptation in the neural response, the response to electrical stimulation was adapted when it was preceded by the associated visual stimulus. Altogether, our results show ACLS can learn, in real-time, to generate specific patterns of neural activity, providing a framework for using closed-loop learning to control neural activity.

Target Audience: Neuroscientists, Biomedical Engineering, Clinicians. NANS invites all faculty, students and post docs to attend!

Presenter and Co-Author
Sina Tafazoli, PhD MSc
Postdoctoral Research Associate
Buschman Lab, Princeton Neuroscience Institute
Princeton University

Ilknur Telkes, PhD MSc
Postdoctoral fellow
Pilitsis Lab, Department of Neuroscience and Experimental Therapeutics
Albany Medical College

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Past Webinars

December Article: Multiple Stimulation Parameters Influence Efficacy of Deep Brain Stimulation in Parkinsonian Mice
The Journal of Clinical Investigation
Jonathan S. Schor, PhD and Alexandra B. Nelson, MD PhD

Jonathan S. Schor, PhD
Irina Duff, MD PhD


November Article: Continuous Theta-Burst Stimulation in Children With High-Functioning Autism Spectrum Disorder and Typically Developing Children
Frontiers in Integrative Neuroscience
Ali Jannati, Gabrielle Block, Mary A. Ryan, Harper L. Kaye, Fae B. Kayarian, Shahid Bashir, Lindsay M. Oberman, Alvaro Pascual-Leone, and Alexander Rotenberg

Ali Jannati, MD PhD
Irina Duff, MD PhD


October Article: Patient‐Specific Analysis of Neural Activation during Spinal Cord Stimulation for Pain
Neuromodulation: Technology at the Neural Interface 2020 Jul;23(5):572-81
Scott F. Lempka, PhD; Hans J. Zander, MSE; Carlos J. Anaya, BS; Alexandria Wyant, BA; John G. Ozinga IV, PA-C; Andre G. Machado, PhD

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Hans J. Zander, MSE
Ilknur Telkes, PhD MSc


WIKISTIM is a searchable database being populated with data published in the field of neuromodulation. The goals of WIKISTIM are to improve patient care and the quality of research reports, foster communication, reveal research needs, and support the practice of evidence–based medicine.

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