Presented Article: Learning to Control the Brain through Adaptive Closed-Loop Patterned Stimulation Date: Tuesday, February 9, 2021 Time: 3 pm CST / 4 pm EST
Tafazoli S, MacDowell CJ, Che Z, Letai KC, Steinhardt C, Buschman TJ. Learning to Control the Brain through Adaptive Closed-Loop Patterned Stimulation. bioRxiv. 2020 Jan 1.
Stimulation of neural activity is an important scientific and clinical tool, causally testing hypotheses and treating neurodegenerative and neuropsychiatric diseases. However, current stimulation approaches cannot flexibly control the pattern of activity in populations of neurons. To address this, we developed an adaptive, closed-loop stimulation (ACLS) system that uses patterned, multi-site electrical stimulation to control the pattern of activity in a population of neurons. Importantly, ACLS is a learning system; it monitors the response to stimulation and iteratively updates the stimulation pattern to produce a specific neural response. In silico and in vivo experiments showed ACLS quickly learns to produce specific patterns of neural activity (~15 minutes) and was robust to noise and drift in neural responses. In visual cortex of awake mice, ACLS learned electrical stimulation patterns that produced responses similar to the natural response evoked by visual stimuli. Similar to how repetition of a visual stimulus causes an adaptation in the neural response, the response to electrical stimulation was adapted when it was preceded by the associated visual stimulus. Altogether, our results show ACLS can learn, in real-time, to generate specific patterns of neural activity, providing a framework for using closed-loop learning to control neural activity.
Target Audience: Neuroscientists, Biomedical Engineering, Clinicians. NANS invites all faculty, students and post docs to attend!
Presenter and Co-Author Sina Tafazoli, PhD MSc Postdoctoral Research Associate Buschman Lab, Princeton Neuroscience Institute Princeton University
Moderator Ilknur Telkes, PhD MSc Postdoctoral fellow Pilitsis Lab, Department of Neuroscience and Experimental Therapeutics Albany Medical College
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WIKISTIM is a searchable database being populated with data published in the field of neuromodulation. The goals of WIKISTIM are to improve patient care and the quality of research reports, foster communication, reveal research needs, and support the practice of evidence–based medicine.
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